Lorna Ewart: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Ewart, Lorna, Dehne, Eva-Maria, Fabre, Kristin, Gibbs, Susan, Hickman, James, Hornberg, Ellinor, Ingelman-Sundberg, Magnus, Jang, Kyung-Jin, Jones, David R., Lauschke, Volker M., Marx, Uwe, Mettetal,

Journal:

Annual Review of Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.43 MB

english, 2018

2

Can the animal model framework be applied to non-cardiovascular safety pharmacology models?

Lorna C. Ewart, Russell Bialecki, Tim Hammond, Philip Jarvis, Derek Leishmann, Silvana Lindgren, Vicente Martinez, Chris Pollard, Will Redfern, Jon Scatchard, John Sherington, Jean-Pierre Valentin, Ro

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 60 KB

english, 2010

3

An evaluation of the non-invasive faecal pellet assessment method as an early drug discovery screen for gastrointestinal liability

Marks, Louise, Beard, Elizabeth, Cobey, Des, Moore, Nick, Motyer, Victoria, Valentin, Jean-Pierre, Ewart, Lorna

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 724 KB

english, 2013

4

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 5.40 MB

english, 2017

5

Impact and prevalence of safety pharmacology-related toxicities throughout the pharmaceutical life cycle

Will S. Redfern, Russ Bialecki, Lorna Ewart, Tim G. Hammond, Lew Kinter, Silvana Lindgren, Chris E. Pollard, Mike Rolf, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

6

Reproducibility of data following a reduced fasting period in the charcoal meal gastrointestinal (GI) study in rats

Helen Prior, Claire Draper, Lorna Ewart, Louise Marks, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

7

Using the animal model framework to explore translation of safety pharmacology cardiovascular data to phase I clinical trial

Rob Wallis, Russell Bialecki, Lorna Ewart, Tim Hammond, Philip Jarvis, Derek Leishmann, Silvana Lindgren, Vicente Martinez, Chris Pollard, Will Redfern, Jon Scatchard, John Sherington, Jean-Pierre Val

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

8

A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions

Ewart, Lorna, Milne, Aileen, Adkins, Debbie, Benjamin, Amanda, Bialecki, Russell, Chen, Yafei, Ericsson, Ann-Christin, Gardner, Stacey, Grant, Claire, Lengel, David, Lindgren, Silvana, Lowing, Sarah,

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 246 KB

english, 2013

9

How concordant is rodent whole body plethysmography to man?

Lorna C. Ewart, Russell Bialecki, Ann-Christin Ericson, Michael Haley, David Lengel, Helen Prior, Jon Scatchard, Margareta Some, Andrea Tait, Rob Wallis, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 52 KB

english, 2010

10

Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry method

Emily L. Bailey, Claire Grant, Jean-Louis Wang, Jean-Gerard Napoleoni, Lorna Ewart, Pierre Lainee, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

11

The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions

Christopher Keating, Vicente Martinez, Lorna Ewart, Stephen Gibbons, Luke Grundy, Jean-Pierre Valentin, David Grundy

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 982 KB

english, 2010

12

Pharmacokinetic timecourse from rodent GLP studies without disturbance to measured parameters or use of additional animals

Helen Prior, Claire Grant, Lorna Ewart, Kirsty Addie-Jackson, Kirsty Payne, Paul Holme, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 58 KB

english, 2011

13

The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds

Louise Marks, Samantha Borland, Karen Philp, Lorna Ewart, Pierre Lainée, Matthew Skinner, Sarah Kirk, Jean-Pierre Valentin

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

14

Continuing Education Forum. Screening and Treating Children at Risk for Coronary Heart Disease

Jolie E. Ewart, Lorna Schumann

Journal:

Journal of the American Academy of Nurse Practitioners

Year:

1998

Language:

english

File:

PDF, 624 KB

english, 1998

15

Translational cardiovascular toxicity: from animal to man and back

Valentin, Jean-Pierre, Skinner, Matt, Ewart, Lorna

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

16

The anaesthetised guinea-pig: A suitable model for front-loading cardiovascular assessment?

Samantha Borland, Karen Philp, Louise Marks, Matthew Skinner, Pierre Lainee, Lorna Ewart, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

17

Applications of transgenic animals in safety pharmacology

Redfern, Will S., Easter, Alison, Ewart, Lorna C., Bialecki, Russ, Valentin, Jean-Pierre

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 61 KB

english, 2013

18

Analysis of concordance of nonclinical rodent respiratory function measurements to phase i trial outcome using the animal model framework

Ewart, Lorna, Amouzadeh, Hamid, Aylott, Mike, Chapman, Kathryn, Jordaan, Pierre, Leishman, Derek, Locher, Kathrin, Mead, Andy, Murphy, Dennis, Scathcard, Jon, Valentin, Jean-Pierre

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 70 KB

english, 2013

19

The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in Phase I clinical trials

Mead, Andrew N., Amouzadeh, Hamid R., Chapman, Kathryn, Ewart, Lorna, Giarola, Alessandra, Jackson, Samuel J., Jarvis, Philip, Jordaan, Pierre, Redfern, Will, Traebert, Martin, Valentin, Jean-Pierre,

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

20

New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop

Mahony, Catherine, Ashton, Randolph S., Birk, Barbara, Boobis, Alan R., Cull, Tom, Daston, George P., Ewart, Lorna, Knudsen, Thomas B., Manou, Irene, Maurer-Stroh, Sebastian, Margiotta-Casaluci, Luigi

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

File:

PDF, 782 KB

2020

21

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

Fabre, Kristin M., Delsing, Louise, Hicks, Ryan, Colclough, Nicola, Crowther, Damian C., Ewart, Lorna

Journal:

Advanced Drug Delivery Reviews

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

22

Pharmacological validation of a telemetric model for the measurement of bronchoconstriction in conscious rats

Lorna C. Ewart, Michael Haley, Sue Bickerton, Jonathan Bright, Katherine Elliott, Alan McCarthy, Lisa Williams, Sally-Ann Ricketts, Tom Holland, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 758 KB

english, 2010

23

The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator

Grant, Claire, Ewart, Lorna, Muthas, Daniel, Deavall, Damian, Smith, Simon A., Clack, Glen, Newham, Pete

Journal:

Toxicology and Applied Pharmacology

Year:

2016

Language:

english

File:

PDF, 708 KB

english, 2016

24

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

Ewart, Lorna, Fabre, Kristin, Chakilam, Ananthsrinivas, Dragan, Yvonne, Duignan, David B, Eswaraka, Jeetu, Gan, Jinping, Guzzie-Peck, Peggy, Otieno, Monicah, Jeong, Claire G, Keller, Douglas A, de Mor

Journal:

Experimental Biology and Medicine

Year:

2017

Language:

english

File:

PDF, 538 KB

english, 2017

25

Rising to the challenge: applying biofabrication approaches for better drug and chemical product development

Holmes, Anthony M, Charlton, Alex, Derby, Brian, Ewart, Lorna, Scott, Andrew, Shu, Wenmiao

Journal:

Year:

2017

Language:

english

File:

PDF, 834 KB

english, 2017

26

A framework to assess the translation of safety pharmacology data to humans

Jean-Pierre Valentin, Russell Bialecki, Lorna Ewart, Tim Hammond, Derek Leishmann, Silvana Lindgren, Vicente Martinez, Chris Pollard, Will Redfern, Rob Wallis

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 618 KB

english, 2009

27

An evaluation of the non-invasive faecal pellet assessment method as an early development screen for gastrointestinal liability

Louise Marks, Des Cobey, Victoria Motyer, Lorna Ewart, Elizabeth Fantham, Nick Moore, Helen Prior, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

28

The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials

Mead, Andrew, Amouzadeh, Hamid, Chapman, Kathryn, Ewart, Lorna, Giarola, Alessandra, Jackson, Samuel, Jarvis, Philip, Jordaan, Pierre, Redfern, Will, Traebert, Martin, Valentin, Jean-Pierre, Vargas, H

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 46 KB

english, 2016

29

Translational pharmacokinetic–pharmacodynamic modeling of QTc effects in dog and human

Parkinson, Joanna, Visser, Sandra A.G., Jarvis, Philip, Pollard, Chris, Valentin, Jean-Pierre, Yates, James W.T., Ewart, Lorna

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 878 KB

english, 2013

30

Advancing nonclinical innovation and safety in pharmaceutical testing

Baker, Elizabeth J., Beck, Nancy A., Berg, Ellen L., Clayton-Jeter, Helene D., Chandrasekera, P. Charukeshi, Curley, J. Lowry, Donzanti, Bruce A., Ewart, Lorna C., Gunther, Jane M., Kenna, J.Gerry, Le

Journal:

Drug Discovery Today

Year:

2018

Language:

english

File:

PDF, 193 KB

english, 2018

31

Association networks as a tool to predict drug-induced nausea in man

Joanna Glab, Daniel Muthas, Scott Boyer, Matthew Clark, Jean-Pierre Valentin, Lorna Ewart

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

32

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Ainslie, Garrett R., Davis, Myrtle, Ewart, Lorna, Lieberman, Linda A., Rowlands, David J., Thorley, Andrew J., Yoder, Gorm, Ryan, Anne M.

Journal:

Year:

2019

Language:

english

File:

PDF, 869 KB

english, 2019

33

How do the top 12 pharmaceutical companies operate safety pharmacology?

Lorna Ewart, David J. Gallacher, Gary Gintant, Jean-Michel Guillon, Derek Leishman, Paul Levesque, Nick McMahon, Lou Mylecraine, Martin Sanders, Willi Suter, Rob Wallis, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 238 KB

english, 2012

34

Functional assessments in repeat-dose toxicity studies: the art of the possible

Redfern, Will S., Ewart, Lorna C., Lainée, Pierre, Pinches, Mark, Robinson, Sally, Valentin, Jean-Pierre

Journal:

Toxicology Research

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

35

Streamlined functional measurements for early toxicology studies in rodents

Will S. Redfern, Louise Marks, Claire Barnard, Des Cobey, Claire Grant, Katherine Greenwood, Lorna Ewart, Helen Prior, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 58 KB

english, 2011

36

A potential algorithm for predicting drug-induced nausea in man

Lorna Ewart, J. Glab, Will Redfern, Karen Roels, J. Scatchard, G. Vickery, Rob Wallis, J.P. Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 57 KB

english, 2011

37

EF50: A non-invasive measure of bronchoconstriction in rats?

Lorna Ewart, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

38

Translational predictive value of safety pharmacology models to humans: A literature based retrospective analysis

Valentin, Jean-Pierre, Ewart, Lorna, Morgan, P.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 67 KB

english, 2014

39

Evaluating Associations between Non-Clinical Cardiovascular Functional Endpoints and Repeat-Dose Cardiovascular Toxicity in the Beagle Dog: A Cross-Company Initiative

Milliken, Philip, Aylott, Mike, Edmunds, Nick, Engle, Steven, Ewart, Lorna, Fleurance, Renaud, Guffroy, Magali, Hargreaves, Adam, Heinz-Taheny, Kathleen, Kirk, Sarah, Leishman, Derek, Leong, Louise, M

Journal:

Toxicological Sciences

Year:

2020

File:

PDF, 1.45 MB

2020

40

Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina,

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 666 KB

english, 2018

41

Measurement of bronchoconstriction in conscious rats: Elegant technique, elusive recordings

Lorna C. Ewart, Katherine Elliott, Michael Haley, Tom Holland, Sally-Ann Ricketts, Alan McCarthy, Lisa Williams, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 57 KB

english, 2010

42

An analysis of safety pharmacology operations across the top 12 pharmaceutical companies

Lorna Ewart, David Gallacher, Gary Gintant, Jean-Michel Guillon, Derek Leishman, Nick McMahon, Paul Levesque, Lou Mylecraine, Willi Suter, Martin Sanders, Rob Wallis, Jean Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

43

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

Peters, Matthew F., Choy, Allison L., Pin, Carmen, Leishman, Derek J., Moisan, Annie, Ewart, Lorna, Guzzie-Peck, Peggy J., Sura, Radhakrishna, Keller, Douglas A., Scott, Clay W, Kolaja, Kyle L.

Journal:

Year:

2020

File:

PDF, 355 KB

2020

44

Non-invasive methods of body temperature measurements in rats

Helen Prior, Victoria Motyer, Louise Marks, Des Cobey, Lorna Ewart, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

45

Inclusion of microchip transponder body temperature measurements in safety pharmacology and toxicology studies

Helen Prior, Victoria Motyer, Des Cobey, Louise Marks, Lorna Ewart, Jean-Pierre Valentin, Will Redfern

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

46

Whole body plethysmography via IV infusions, without the need for surgical preparation

Helen Prior, Lorna Ewart, Claire Barnard, Nick Moore, Jean-Pierre Valentin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 53 KB

english, 2009

47

Preclinical observation profiles – The sum of findings are greater than the parts

Daniel Muthas, Joanna Parkinson, Matthew Clark, Jean-Pierre Valentin, Scott Boyer, Lorna Ewart

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 88 KB

english, 2012

48

A peripherally restricted P2Y12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism

Brott, David A., Andersson, Håkan A.S., Stewart, Jane, Ewart, Lorna, Christoph, Greg, Harleman, Johannes, Armstrong, Duncan, Kinter, Lewis B.

Journal:

Toxicology Reports

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски